Pranav S. Renavikar, MD


Visiting Post Doctoral Research Scholar

Pranav Renavikar

pranav-renavikar@uiowa.edu

Department of Pathology
1080 Medical Laboratories
500 Newton Road
University of Iowa
Iowa City, IA 52242

Lab: 319-335-7630

I come to the Hawkeye state from Pune, India. After graduating medical college, I joined Dr. Karandikar’s lab as a research scholar. Our lab’s primary research focus is to understand the immunological interactions between CD4 and CD8 T-cells in the context of autoimmune disorders like Multiple Sclerosis and its mouse model, Experimental Autoimmune Encephalomyelitis. I study the immune-regulatory role of CD8 T-cells through mechanistic experiments to look at different autoimmunity related molecules, cytokines and genes. I plan to use this training and experience to diversify our know-how and potentially contribute to upgraded therapies for Multiple Sclerosis.

Published articles/abstracts:

  1. Renavikar, P.S., Crawford, M.P., Sinha, S. and Karandikar N.J. Human Tc17 cells harbor potent immune suppressive potential, whereas Tc1 cells lack suppressive ability. Journal of Immunology. 2019, May; 202(1 Supplement): 57.13

  2. Crawford, M.P., Sinha, S., Renavikar, P.S., and Karandikar N.J. CD4+ T-helper 17 (Th17) signature cytokine, IL-17, mediates CD4 resistance to immune suppression. Journal of Immunology. 2019, May; 202(1 Supplement): 57.11

  3. Sinha, S., Renavikar, P.S., Crawford, M.P., Rodgers, J.W., Tsalikian, E., Tansey, M. and Karandikar, N.J. Autoimmunity-associated intronic SNP (rs2281808) detected by a simple phenotypic assay: Unique case or broader opportunity?. Clinical Immunology. 2019, Jan; 198(1): 57-61

  4. Sinha, S., Borcherding, N., Renavikar, P.S., Crawford, M.P., Tsalikian, E., Tansey, M., Shivapour, E.T., Bittner, F., Kamholz, J.,Olalde, H., Gibson, E. and Karandikar, N.J.. An autoimmune disease risk SNP, rs2281808, in SIRPG is associated with reduced expression of SIRPg and heightened effector state in human CD8 T-cells. Scientific Reports. 2018, Oct; 8(1): 15440